Benzimidazole Intermediates for Pharmaceutical APIs
Benzimidazole is an important pharmaceutical scaffold. Brominated and methylated benzimidazole intermediates provide the handles needed for API synthesis and medicinal chemistry programs.
Why benzimidazole intermediates matter
Key targets include proton pump inhibitors Omeprazole and Esomeprazole, the anticoagulant Dabigatran etexilate, and anthelmintics such as Albendazole and Mebendazole.
Representative building blocks
- 5-Bromo-1H-benzimidazole (CAS 4887-88-1): brominated benzimidazole scaffold for API synthesis
- 5-Bromo-2-methyl-1H-benzoimidazole (CAS 1964-77-8): methylated bromobenzimidazole for further substitution
- Benzimidazole intermediates support proton pump inhibitor, anticoagulant and anthelmintic chemistry
Procurement notes
Confirm the exact substitution position and CAS number because benzimidazole isomers can be close in name but different in structure. Request COA and purity data for the batch before ordering.
Representative products
- 5-bromo-1H-benzimidazole (CAS 4887-88-1)
- 5-bromo-2-methyl-1H-benzoimidazole (CAS 1964-77-8)
- 1H-benzimidazole-2-carboxaldehyde (CAS 3314-30-5)
- 5-methoxybenzimidazole (CAS 4887-80-3)
- 2-methyl-5-methoxybenzimidazole (CAS 4887-81-4)
- 2-Methylbenzimidazole (CAS 615-15-6)
Related product categories
Frequently asked questions
What APIs use benzimidazole intermediates?
Examples include proton pump inhibitors, the anticoagulant Dabigatran etexilate and anthelmintic medicines.
Are brominated benzimidazoles suitable for cross-coupling?
Brominated benzimidazoles are commonly used as coupling partners, but the reaction should be validated for the specific scaffold and substitution pattern.
Can you confirm current purity and packaging?
Yes. Send the CAS number and target quantity to request current batch information.
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