Halogenated Aromatic Building Blocks for Cross-Coupling Chemistry
Aryl halides are foundational building blocks in modern organic synthesis. The position and type of halogen determine how the building block can be used in cross-coupling and functional group chemistry.
Why aryl halides are useful
Brominated, chlorinated and iodinated aromatics are standard entry points for Suzuki, Buchwald and related cross-coupling reactions. Reactivity generally follows iodide greater than bromide greater than chloride, while bromides offer a good balance of stability and reactivity.
Representative products
- 1-Bromo-2,4-dimethoxybenzene (CAS 17715-69-4): dimethoxyaryl bromide for pharmaceutical and OLED/OPV monomer chemistry
- 2-Bromo-1,4-dimethoxybenzene (CAS 25245-34-5): regioisomeric dimethoxyaryl bromide
- 1,2-Dibromo-4-iodobenzene (CAS 909072-74-8): multihalogenated aryl building block for sequential cross-coupling
How to compare building blocks
Match the halogen positions to your planned disconnection, check purity and packaging, and verify the CAS number before ordering. For sequential coupling, different halogens allow stepwise functionalization.
Representative products
- 1-Bromo-2,4-dimethoxybenzene (CAS 17715-69-4)
- 2-bromo-1,4-dimethoxybenzene (CAS 25245-34-5)
- 4-bromoveratrole (CAS 2859-78-1)
- 1,2-Dibromo-4-iodobenzene (CAS 909072-74-8)
- 2,5-Dibromo-m-xylene (CAS 100189-84-2)
- 1-Bromo-2,3,4-trimethoxybenzene (CAS 10385-36-1)
Related product categories
Frequently asked questions
Which halogen should I choose for cross-coupling?
The choice depends on reactivity, cost and selectivity. Bromides are common for aryl coupling, while iodides are more reactive and chlorides are more economical.
Are methoxy-substituted aryl bromides in the catalog?
Yes. Examples include 1-bromo-2,4-dimethoxybenzene and 2-bromo-1,4-dimethoxybenzene, which differ by substitution position.
Can I request a multihalogenated building block?
Confirm the CAS number and target quantity, and our team can check availability and specifications.
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