Indazole and Indole Intermediates for Medicinal Chemistry
Indazole and indole derivatives are widely used in medicinal chemistry programs. Their nitrogen-containing rings and substitution patterns make them valuable scaffolds for API development.
Why these scaffolds matter
These scaffolds are used in oncology APIs such as Axitinib, Pazopanib and Niraparib, and serotonin/triptan APIs such as Sumatriptan and Rizatriptan.
Representative building blocks
- 4-Methyl-1H-indazol-5-amine (CAS 101257-89-0): aminomethylindazole building block
- 5-Aminoindazole (CAS 19335-11-6): aminoindazole scaffold for medicinal chemistry
- 5-Iodo-1H-indazole (CAS 55919-82-9): iodinated indazole for cross-coupling
Sourcing notes
Confirm the exact substitution position and CAS number before ordering. Indazole and indole isomers can have very different reactivity and downstream targets.
Representative products
- 4-methyl-1H-indazol-5-amine (CAS 101257-89-0)
- 5-Aminoindazole (CAS 19335-11-6)
- 5-iodo-1H-indazole (CAS 55919-82-9)
- 5-Amino-4-chloro-1H-indazole (CAS 1082041-33-5)
- 6-iodoindazole (CAS 261953-36-0)
- 4-Aminoindazole (CAS 41748-71-4)
Related product categories
Frequently asked questions
Are indazole and indole the same scaffold?
No. They are different heterocycles. Indazole has two adjacent nitrogen atoms, while indole has one nitrogen atom in the five-membered ring.
What applications use these intermediates?
Oncology APIs and CNS/neurology chemistry are common application areas.
Can I request a custom substitution?
Share the target structure or CAS number and quantity; feasibility can be confirmed by our sales and technical team.
Request a quotation
Send the CAS number and target quantity to [email protected] or message us on WhatsApp.
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